Aging.
Evidence-led reading on aging from the HL Benefits desk. Long reads, careful guides, and the boring-but-true positions the research keeps settling on.
SGLT2 Inhibitors for Longevity: The Diabetes Drug With Anti-Aging Potential
SGLT2 inhibitors extended mouse lifespan by 14% and cut human cardiovascular mortality by 38%. The science behind their anti-aging potential.
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Rapamycin Side Effects and Safety: What Bryan Johnson's Experience Tells Us
A research-backed guide to rapamycin's side effects at anti-aging doses, from blood glucose changes to immune impacts, plus what Bryan Johnson's five-year experiment revealed.
Peptide Therapy Beyond BPC-157: TB-500, GHK-Cu, and What's Legal in 2026
AgingMetabolic Drug Repurposing: SGLT2 Inhibitors, Acarbose, and Off-Label Anti-Aging
AgingEpigenetic Reprogramming: The Anti-Aging Therapy Entering Human Trials in 2026
Bryan Johnson Blueprint Protocol: What the $2M/Year Anti-Aging Regimen Actually Involves
A detailed breakdown of Bryan Johnson's Blueprint protocol, separating evidence-backed interventions from expensive experiments.
Senolytic Supplements: Fisetin, Quercetin, and Clearing Zombie Cells
A research-backed guide to senolytic supplements that target senescent zombie cells, covering fisetin, quercetin, clinical trial data, and safety.
Urolithin A: The Mitochondrial Anti-Aging Supplement Most People Haven't Heard Of
Urolithin A activates mitophagy, the cellular process that clears out damaged mitochondria. Clinical trials show real benefits for muscle and overall aging.
We started this section because the conversation about aging had become unbearable — too loud, too certain, too often selling something. The boring middle — what the evidence actually supports, repeated across decades, written without a brand to defend — is not a position you can monetize, but it is the position the research keeps quietly settling on.
Companion sections.
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A companion section to aging, with its own evidence-led reading list.
Food & Nutrition
A companion section to aging, with its own evidence-led reading list.
Fitness
A companion section to aging, with its own evidence-led reading list.
Definitive guides.
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Spermidine for Autophagy and Anti-Aging: The Compound Hidden in Everyday Foods
Spermidine activates autophagy, your body's cellular recycling system, and research links higher dietary intake to reduced cardiovascular disease and longer lifespan.
Telomere Length: Can You Actually Slow Cellular Aging?
Telomeres protect your chromosomes from damage during cell division. Learn what science says about preserving telomere length.
A claim about aging is not a study. A study is not a meta-analysis. A meta-analysis is not a guideline. The article doesn't fit on a label.
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Spermidine: The Longevity Compound in Wheat Germ That Triggers Autophagy
Spermidine, a polyamine concentrated in wheat germ, activates autophagy and shows strong links to reduced mortality in human epidemiological studies.
Urolithin A: The Gut-Derived Compound That Fights Muscle Aging
Urolithin A triggers mitophagy to clear damaged mitochondria and improve muscle strength. Learn what the clinical trials show and how to get it.