Aging.
Evidence-led reading on aging from the HL Benefits desk. Long reads, careful guides, and the boring-but-true positions the research keeps settling on.
NAD+ and NMN Supplements for Aging and Cellular Repair
NAD+ levels decline with age, impairing energy production and DNA repair. Clinical trials show NMN supplements can raise NAD+ levels and improve walking speed, sleep, and metabolic markers.
Photograph · HL BenefitsThe latest, in long form.
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Rapamycin and Longevity: The Anti-Aging Drug Researchers Are Watching
Rapamycin extends lifespan in every species tested so far. But does the evidence support using this transplant drug for human longevity?
Urolithin A: The Gut-Derived Compound That Fights Muscle Aging
AgingSpermidine: The Longevity Compound in Wheat Germ That Triggers Autophagy
AgingTelomere Length: Can You Actually Slow Cellular Aging?
Spermidine for Autophagy and Anti-Aging: The Compound Hidden in Everyday Foods
Spermidine activates autophagy, your body's cellular recycling system, and research links higher dietary intake to reduced cardiovascular disease and longer lifespan.
Urolithin A: The Mitochondrial Anti-Aging Supplement Most People Haven't Heard Of
Urolithin A activates mitophagy, the cellular process that clears out damaged mitochondria. Clinical trials show real benefits for muscle and overall aging.
Senolytic Supplements: Fisetin, Quercetin, and Clearing Zombie Cells
A research-backed guide to senolytic supplements that target senescent zombie cells, covering fisetin, quercetin, clinical trial data, and safety.
We started this section because the conversation about aging had become unbearable — too loud, too certain, too often selling something. The boring middle — what the evidence actually supports, repeated across decades, written without a brand to defend — is not a position you can monetize, but it is the position the research keeps quietly settling on.
Companion sections.
All sections →Health
A companion section to aging, with its own evidence-led reading list.
Food & Nutrition
A companion section to aging, with its own evidence-led reading list.
Weight Loss
A companion section to aging, with its own evidence-led reading list.
Definitive guides.
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Bryan Johnson Blueprint Protocol: What the $2M/Year Anti-Aging Regimen Actually Involves
A detailed breakdown of Bryan Johnson's Blueprint protocol, separating evidence-backed interventions from expensive experiments.
Epigenetic Reprogramming: The Anti-Aging Therapy Entering Human Trials in 2026
The first human trial of epigenetic reprogramming has begun. ER-100 targets age-related eye disease using three Yamanaka factors to reverse cellular aging.
A claim about aging is not a study. A study is not a meta-analysis. A meta-analysis is not a guideline. The article doesn't fit on a label.
On our desk this week.
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Metabolic Drug Repurposing: SGLT2 Inhibitors, Acarbose, and Off-Label Anti-Aging
Two diabetes drugs are producing longevity data that rivals rapamycin. Here is what the research shows about SGLT2 inhibitors and acarbose for aging.
Peptide Therapy Beyond BPC-157: TB-500, GHK-Cu, and What's Legal in 2026
The FDA banned 19 peptides in 2023. Now RFK Jr. wants to reverse the ban. Here is what the research says about BPC-157, TB-500, and GHK-Cu.
Quick reads.
All 21 →Anti-Aging Peptides for Women Over 50: The Hormone-Friendly List
A conservative guide to anti-aging peptides after menopause, focused on skin support,…
Anti-Aging Peptides for Men Over 40: A Doctor's Honest Protocol
A conservative, evidence-tiered protocol for men over 40 considering peptides, with…
Bryan Johnson's Peptide Stack — Decoded for Mortals on a Normal Budget
Bryan Johnson's public peptide story is narrower than the internet claims. Here's what…
CJC-1295 + Ipamorelin: The Stack Behind Hollywood's Quiet Body Transformations
Why Hollywood prefers CJC-1295 paired with Ipamorelin over exogenous HGH — the…