Issue · Apr 2026New this week: evidence-first longevity readsThe newsletter — one essay, Sunday morningsArchive access — every article, free to readPodcast coming soon — NotebookLM sessionsLetters from readers — reply to any emailIssue · Apr 2026New this week: evidence-first longevity readsThe newsletter — one essay, Sunday morningsArchive access — every article, free to readPodcast coming soon — NotebookLM sessionsLetters from readers — reply to any email
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Compounded Semaglutide: How to Tell a Safe Source from a Dangerous Knockoff
Weight Loss

Compounded Semaglutide: How to Tell a Safe Source from a Dangerous Knockoff

After the FDA declared the semaglutide shortage resolved in February 2025, the legal market for compounded GLP-1s narrowed sharply while a black market expanded. This guide walks through 503A vs 503B vs research peptides, the salt-form red flag, counterfeit incidents on record, and the credentialing checklist and questions that separate a legitimate compounding pharmacy from a dangerous knockoff.

Apr 24 · 16 min readBy J. (JessieLew)
The long read

A slower piece, on one thing.

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Wearable Patches for Health: CGM, Vitamin Delivery, and Drug Monitoring
Tech · In-depth essay

Wearable Patches for Health: CGM, Vitamin Delivery, and Drug Monitoring

OTC glucose monitors, vitamin patches, and biosensor innovations are reshaping personal health tracking. Here's what works, what doesn't, and what's next.

Begin reading13 min readBy Jessica Lewis (JessieLew)
Letter from the editorial team

On the quiet parts of getting well.

Tirzepatide drives an average 22.5% body-weight loss in trials — but stopping the drug leads to roughly 14% regain in a year, even with diet and exercise.

The goal isn’t to be comfortable with change — it’s to be comfortable with one small change, on a schedule, held for a year.

From “Why Tirzepatide Users Lose 22% of Their Body Weight — and What Happens When They Stop” · The HL Benefits Editorial Team · Apr 2026
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