Issue · Aug 2026New this week: evidence-first longevity readsThe newsletter — one essay, Sunday morningsArchive access — every article, free to readPodcast coming soon — NotebookLM sessionsLetters from readers — reply to any emailIssue · Aug 2026New this week: evidence-first longevity readsThe newsletter — one essay, Sunday morningsArchive access — every article, free to readPodcast coming soon — NotebookLM sessionsLetters from readers — reply to any email

Weight
Loss.

Sustainable weight loss, evidence-first — what diet, movement, and sleep actually do for appetite, satiety, and lasting results.

In this section
46longreads
Newest
Jun 102016
Section since
2016archive
Reading time
~8min average
This week's longread

Lose Extra Weight and Keep It Off: 20 Evidence-Based Steps

Read the articleHL Benefits Editorial · Jun 10, 2016
Adults preparing balanced, portion-aware meal bowls with vegetables, whole grains, and lean proteins in a bright kitchenPhotograph · HL Benefits
§ 01

The latest, in long form.

Browse all 46
Adults meal-prepping balanced dishes with vegetables, lean protein, and whole grains in a bright kitchen
CoverWeight Loss

How to Shed Pounds and Keep Them Off

Jun 18
Can Yoga Help With Weight Loss? - Weight Loss
Weight Loss

Can Yoga Help With Weight Loss?

Mar 22
Balanced whole-food meal composition designed to support satiety and metabolic control
Weight Loss

Nature-Identical GLP-1 Support: What Actually Works

A practical, evidence-based guide to natural GLP-1 support with food strategy, sleep timing, and safety warnings on unapproved products.

Jan 28
Person performing a heavy barbell squat in a modern gym representing resistance training protocols for GLP-1 muscle preservation
Weight Loss

GLP-1 Muscle Sparing Protocol: What Actually Works

GLP-1 therapy can cause significant muscle loss. Discover evidence-based protocols using protein, resistance training, and supplements to protect lean mass.

Feb 19
§ 02

Companion sections.

All sections →
206 articles · ongoing

Health

A companion section to weight loss, with its own evidence-led reading list.

Read the section
79 articles · ongoing

Food & Nutrition

A companion section to weight loss, with its own evidence-led reading list.

Read the section
39 articles · ongoing

Fitness

A companion section to weight loss, with its own evidence-led reading list.

Read the section
§ 03

Definitive guides.

All guides →
Injectable GLP-1 medication pen next to a digital scale in a modern clinical setting
Guide

GLP-1 Drugs, Celebrity Bodies, and the Ethics of Modern Weight Loss

What you should know about GLP-1 drugs, their real risks, and why celebrity culture makes the conversation harder.

Feb 26
Assortment of natural fat-burning ingredients including green tea leaves, chili peppers, and berberine capsules arranged on a wooden surface
Guide

Natural Fat Burners: Evidence-Based Strategies for Sustainable Weight Loss

An evidence-based guide to natural fat burners including berberine, green tea extract, and capsaicinoids, with honest comparisons to GLP-1 medications.

Mar 4
§ 04

On our desk this week.

More from the desk →
§ 05

Quick reads.

All 46
01

Oral Semaglutide (Rybelsus / Wegovy Pill): The End of Weight Loss Injections?

The FDA approved the first oral GLP-1 for weight loss in December 2025. Clinical trials…

Mar 31
02

Tirzepatide vs Semaglutide (Mounjaro/Zepbound vs Ozempic/Wegovy): Complete Comparison

SURMOUNT-5 trial data comparing tirzepatide and semaglutide head-to-head, with…

Apr 1
03

Retatrutide: The Triple-Agonist Weight Loss Drug Showing 24-29% Body Weight Reduction

Retatrutide achieved 28.7% weight loss in Phase 3 trials -- matching bariatric surgery…

Apr 1
04

GLP-1 Microdosing: The Quiet Trend Replacing Full-Dose Ozempic in 2026

GLP-1 microdosing is everywhere in 2026. Here is what the evidence actually shows about…

Apr 24
05

Compounded Semaglutide: How to Tell a Safe Source from a Dangerous Knockoff

After the FDA declared the semaglutide shortage resolved in February 2025, the legal…

Apr 24
06

AOD-9604: The 'Fat-Burning Fragment' That Promises Results Without Hunger Loss

AOD-9604 is sold as fat loss without hunger. The 24-week trial in 536 people that was…

Apr 24
07

Hit an Ozempic Plateau? 5 Peptide Stacks That May Restart Stalled Weight Loss

Plateaus on GLP-1 drugs are biology, not failure. Here is an evidence-honest review of…

Apr 25
08

I Tried Semaglutide for 90 Days: The Honest Before-and-After Nobody Talks About

What 90 days of semaglutide actually changes — pulled from STEP-1, STEP-4, and…

Apr 25
§ 06

From the archive.

All 46
Retatrutide Is Being Called the "Godzilla" of Weight Loss — Here's What Phase 3 Trials Just Revealed
Weight Loss

Retatrutide Is Being Called the "Godzilla" of Weight Loss — Here's What Phase 3 Trials Just Revealed

Apr 25
Tirzepatide vs. Semaglutide: Which GLP-1 Peptide Actually Melts More Fat?
Weight Loss

Tirzepatide vs. Semaglutide: Which GLP-1 Peptide Actually Melts More Fat?

Apr 26
The 7 Most Effective Weight Loss Peptides Doctors Are Quietly Recommending in 2026
Weight Loss

The 7 Most Effective Weight Loss Peptides Doctors Are Quietly Recommending in 2026

Apr 26
The Stubborn Belly Fat Peptide: Why Tesamorelin Is Going Viral with Women Over 40
Weight Loss

The Stubborn Belly Fat Peptide: Why Tesamorelin Is Going Viral with Women Over 40

Apr 26
Why Tirzepatide Users Lose 22% of Their Body Weight — and What Happens When They Stop
Weight Loss

Why Tirzepatide Users Lose 22% of Their Body Weight — and What Happens When They Stop

Tirzepatide drives an average 22.5% body-weight loss in trials — but stopping the drug leads to roughly 14% regain in a year, even with diet and exercise.

Apr 27
The GLP-1 Side Effect List Your Doctor Probably Won't Mention
Weight Loss

The GLP-1 Side Effect List Your Doctor Probably Won't Mention

Most patients on Ozempic, Wegovy, or Zepbound hear about nausea and stop there. The full safety profile includes lean muscle loss, sulfur burps, gallstones, NAION vision risk, anesthesia warnings,…

Apr 27
Liraglutide vs. Semaglutide vs. Tirzepatide: A Plain-English Comparison Chart
Weight Loss

Liraglutide vs. Semaglutide vs. Tirzepatide: A Plain-English Comparison Chart

How the three big GLP-1 drugs really compare on weight loss, cardiovascular benefit, dosing schedule, side effects, and cost.

Apr 27
Weight Loss Peptides After 50: What Changes for Women in Perimenopause
Weight Loss

Weight Loss Peptides After 50: What Changes for Women in Perimenopause

Tirzepatide and semaglutide produce nearly identical weight loss across reproductive stages. Pairing GLP-1 peptides with HRT increases loss by ~30%.

Apr 30
Why Compounded Peptides Cost 80% Less Than Brand-Name GLP-1s
Weight Loss

Why Compounded Peptides Cost 80% Less Than Brand-Name GLP-1s

The same semaglutide molecule, 80% less. Here's where every dollar goes and why the price gap is shrinking.

May 16
Peptides for Stubborn Menopausal Belly Fat: The Tesamorelin Conversation Continues
Weight Loss

Peptides for Stubborn Menopausal Belly Fat: The Tesamorelin Conversation Continues

Visceral fat doubles during menopause. Tesamorelin has clinical data for reduction, but all trials are in HIV patients. What menopausal women should know.

May 27

The BriefOne slow read about weight loss, every Thursday morning.

Quiet readers welcome · unsubscribe in one click